Vorhees C V, Brunner R L, Butcher R E
Science. 1979 Sep 21;205(4412):1220-5. doi: 10.1126/science.472738.
Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means.
给怀孕的大鼠施用了三种精神药物，然后评估它们对后代行为和生殖的影响。对照大鼠接受生理盐水或维生素A。丙氯拉嗪对生殖和生长的干扰作用最大，但对行为的影响最小。丙氧芬对生殖或生长没有明显影响，但产生了多种行为变化。芬氟拉明对生殖和生长的影响处于中等水平，并且在断奶前发育测试中显示出行为影响。数据表明，行为的系统测试为生殖毒性评估增添了重要信息，而目前通过其他方法无法获得这些信息。
