Nestel P J, Schreibman P H, Ahrens E H
J Clin Invest. 1973 Oct;52(10):2389-97. doi: 10.1172/JCI107428.
An experiment was undertaken to test whether in severe obesity cholesterol production rates obtained by isotope kinetic analysis (two-pool compartmental analysis) are comparable to those measured by chemical sterol balance techniques. Eight severely obese but normocholesterolemic patients were studied by the balance method, and five of these eight were studied by compartmental analysis. Cholesterol turnover was 10% higher by compartmental analysis. In the entire group of eight patients cholesterol turnover was greater than twice that found previously in nonobese patients studied under similar conditions with bile acids and neutral sterols both participating in the increase. This increment was directly related to excess body fat and to adipose cellularity, with correlation co-efficients of 0.66 and 0.72, respectively. The amount of cholesterol in the slowly turning over pool B was related to degree of adiposity, but that in plasma and in pool A did not differ from values in nonobese patients.
进行了一项实验，以测试在严重肥胖症中，通过同位素动力学分析（双池房室分析）获得的胆固醇生成率是否与通过化学甾醇平衡技术测量的结果相当。通过平衡法对8名严重肥胖但胆固醇正常的患者进行了研究，其中5名患者通过房室分析进行了研究。通过房室分析，胆固醇周转率高10%。在这8名患者的整个组中，胆固醇周转率大于先前在类似条件下研究的非肥胖患者的两倍，胆汁酸和中性甾醇均参与了这种增加。这种增加与身体脂肪过多和脂肪细胞数量直接相关，相关系数分别为0.66和0.72。缓慢周转池B中的胆固醇量与肥胖程度有关，但血浆和池A中的胆固醇量与非肥胖患者的值没有差异。
