Korman M G, Hansky J, Strickland R G
Gut. 1973 Jul;14(7):549-51. doi: 10.1136/gut.14.7.549.
Patients with atrophic gastritis but normal antral mucosa and achlorhydria were divided into three groups according to age-under 40, 40 to 70, and over 70 years. Serum gastrin, both basal and following a standard protein meal, was estimated in all patients by radioimmunoassay. There was a significant correlation between the magnitude of the gastrin response and age, the older the patient the greater the response. These results suggest that with increasing duration of gastritis and continued stimulation of a normal antrum in the absence of inhibition by acid, the functional G (gastrin) cell mass increases. However the possibility exists that each cell may secrete more gastrin in response to the same stimulus with age. This may be resolved by counting the number of G cells in the stomachs of subjects with atrophic gastritis and different ages.
患有萎缩性胃炎但胃窦黏膜正常且胃酸缺乏的患者，根据年龄分为三组：40岁以下、40至70岁以及70岁以上。通过放射免疫分析法对所有患者的基础血清胃泌素以及标准蛋白质餐后的血清胃泌素进行了测定。胃泌素反应的幅度与年龄之间存在显著相关性，患者年龄越大，反应越强。这些结果表明，随着胃炎病程的延长以及正常胃窦在无酸抑制情况下持续受到刺激，功能性G（胃泌素）细胞群会增加。然而，存在这样一种可能性，即随着年龄增长，每个细胞在受到相同刺激时可能会分泌更多胃泌素。这可以通过对不同年龄的萎缩性胃炎患者的胃中G细胞数量进行计数来解决。
