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Methadone and brain development.

作者信息

Zagon I S, McLaughlin P J

出版信息

Experientia. 1977 Nov 15;33(11):1486-7. doi: 10.1007/BF01918824.

DOI:10.1007/BF01918824
PMID:923719
Abstract

The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of offspring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%, respectively), and DNA values (50% and 34%, respectively) observed.

摘要

相似文献

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Methadone and brain development.
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本文引用的文献

1
Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.动物组织中的磷化合物；脱氧戊糖核酸和戊糖核酸的提取与测定
J Biol Chem. 1945;161:293-303.
2
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
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Growth and development of the brain and spinal cord of the guinea pig.
纳曲酮植入疗法改善了代谢血糖、免疫功能和动脉僵硬度参数。
BMJ Case Rep. 2009;2009:bcr0820080799. doi: 10.1136/bcr.08.2008.0799. Epub 2009 Apr 14.
4
The effects of maternally administered methadone, buprenorphine and naltrexone on offspring: review of human and animal data.美沙酮、丁丙诺啡和纳曲酮对母婴的影响：人类和动物数据综述。
Curr Neuropharmacol. 2008 Jun;6(2):125-50. doi: 10.2174/157015908784533842.
5
Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability.小脑颗粒神经母细胞及其后代对具有成瘾性药物的选择性易损性。
Cerebellum. 2003;2(3):184-95. doi: 10.1080/14734220310016132.
6
Protracted analgesia in young and adult rats maternally exposed to methadone.母体接触美沙酮的幼年和成年大鼠的持续性镇痛
Experientia. 1980 Mar 15;36(3):329-30. doi: 10.1007/BF01952306.
Brain Res. 1970 Jan 6;17(1):115-23. doi: 10.1016/0006-8993(70)90311-2.
4
Growth retardation in young mice treated with d1-methadone.用d1-美沙酮治疗的幼鼠生长迟缓。
Science. 1973 Sep 7;181(4103):947-9. doi: 10.1126/science.181.4103.947.
5
Teratogenic activity of methadone hydrochloride in mouse and chick embryos.盐酸美沙酮对小鼠和鸡胚胎的致畸活性。
J Embryol Exp Morphol. 1973 Oct;30(2):449-58.
6
Drug addiction in pregnancy and the neonate.
Am J Obstet Gynecol. 1976 May 15;125(2):135-42. doi: 10.1016/0002-9378(76)90583-4.
7
Somatic growth effects of perinatal addiction.围产期成瘾对躯体生长的影响。
Addict Dis. 1975;2(1-2):333-45.
8
Effect of chronic maternal methadone exposure on perinatal development.
Biol Neonate. 1977;31(5-6):271-82. doi: 10.1159/000240975.
9
The effects of different schedules of methadone treatment on rat brain development.
Exp Neurol. 1977 Sep;56(3):538-52. doi: 10.1016/0014-4886(77)90320-x.
10
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.仓鼠中麻醉性镇痛药所致的中枢神经系统先天性畸形
Am J Obstet Gynecol. 1975 Dec 1;123(7):705-13. doi: 10.1016/0002-9378(75)90492-5.