Hutchinson R M, Merrick M V, White J M
J Clin Pathol. 1973 Aug;26(8):620-2. doi: 10.1136/jcp.26.8.620.
Fat embolism is a known complication of marrow infarction in patients with sickle cell disease (Hb S/S and Hb S/C) disease. It should be considered in sickle cell crisis when there is deterioration in respiratory function, a fall in arterial PO(2), a normoblastaemia, and a thrombocytopenia in the peripheral blood. We now report a patient in whom the diagnosis was confirmed in life by identifying fat in the sputum, demonstrating disseminated intravascular coagulation, and using a double isotope technique to distinguish recent from old marrow infarction. Use of these features enabled an early diagnosis to be made which led to a successful outcome in a potentially fatal condition.
脂肪栓塞是镰状细胞病（Hb S/S和Hb S/C）患者骨髓梗死的一种已知并发症。当镰状细胞危象患者出现呼吸功能恶化、动脉血氧分压下降、正细胞性贫血以及外周血血小板减少时，应考虑脂肪栓塞。我们现报告一例患者，通过在痰液中发现脂肪、证实弥散性血管内凝血以及使用双同位素技术区分近期与陈旧性骨髓梗死，在患者生前确诊了脂肪栓塞。利用这些特征得以早期诊断，从而在这一潜在致命疾病中取得了成功的治疗结果。
