Shek P N, Dubiski S
J Immunol. 1975 Feb;114(2 Pt 1):621-5.
Neonatal injection with various foreign proteins (normal goat serum, human Cohn fraction II, human albumin) caused a stimulation of immunoglobulin synthesis. This effect was not antigen-specific and did not constitute a conventional antibody response directed against the injected substance. When this stimulatory effect of foreign protein was minimized, the heterologous (goat) anti-rabbit allotype antibody and rabbit antibody F(ab') 2 fragments not only failed to induce suppression but also competed with the suppression-inducing native rabbit antibody. Allotypic suppression in a rabbit can thus only be induced by an antibody molecule possessing an intact Fc portion of isologous, rabbit origin. Antibody to Ae14, an allotypic specificity located on the Fc portion, failed to induce suppression or stimulation of immunoglobulin synthesis. This was attributed to the position of Ae14 in the cell membrane which reduced its accessibility to antibody.
新生兔注射各种外源蛋白（正常山羊血清、人Cohn组分II、人白蛋白）会刺激免疫球蛋白的合成。这种效应并非抗原特异性的，也不构成针对注射物质的传统抗体反应。当外源蛋白的这种刺激效应减至最小时，异源（山羊）抗兔同种异型抗体和兔抗体F(ab')2片段不仅不能诱导抑制，反而与诱导抑制的天然兔抗体竞争。因此，兔体内的同种异型抑制只能由具有完整Fc部分的同源兔源抗体分子诱导。针对位于Fc部分的同种异型特异性Ae14的抗体，既不能诱导免疫球蛋白合成的抑制，也不能诱导其刺激。这归因于Ae14在细胞膜上的位置，使其难以与抗体接触。
