威斯科特-奥尔德里奇综合征（WAS）患者中植物血凝素诱导的细胞毒性效应淋巴细胞功能。
Phytohaemagglutinin-induced cytotoxic effector lymphocyte function in patients with the Wiskott-Aldrich syndrome (WAS).
作者信息
Sherwood G, Blaese R M
出版信息
Clin Exp Immunol. 1973 Apr;13(4):515-20.
Abstract
Patients with the Wiskott–Aldrich syndrome have immunodeficiency characterized by defective antibody production and clinical anergy. lymphocyte proliferative responses to non-specific mitogens in these patients, however, are normal. To determine if their anergy might be the result of failure to produce cytotoxic effector lymphocytes, peripheral blood leucocytes were cultured with Cr-labelled chicken erythrocyte targets in the presence of PHA. Lymphocytes from patients with the Wiskott-Aldrich syndrome had normal PHA induced cytotoxicity responses and this result is discussed in relation to a postulated defect in the afferent limb of the immune response.
摘要
患有维斯科特-奥尔德里奇综合征的患者存在免疫缺陷，其特征为抗体产生缺陷和临床无反应性。然而，这些患者对非特异性有丝分裂原的淋巴细胞增殖反应是正常的。为了确定他们的无反应性是否可能是由于未能产生细胞毒性效应淋巴细胞所致，在PHA存在的情况下，将外周血白细胞与铬标记的鸡红细胞靶细胞一起培养。维斯科特-奥尔德里奇综合征患者的淋巴细胞具有正常的PHA诱导的细胞毒性反应，并结合免疫反应传入支中假定的缺陷对这一结果进行了讨论。
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本文引用的文献
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