Gotoff S P
Clin Exp Immunol. 1968 Oct;3(8):843-56.
The lymphocyte response to phytohaemagglutinin (PHA) and antigens was normal in five patients with Bruton-type agammaglobulinaemia. Lymphocytes from one infant with thymic dysplasia failed to respond to PHA. The response to PHA and antigens was variable in three patients with ataxia telangiectasia. The lymphocyte response in these patients appears to reflect the state of thymic-dependent cellular immunity or capacity for delayed hypersensitivity reactions. The lymphocyte response to PHA and antigens was normal in two children with Wiskott-Aldrich Syndrome, a disease in which the immunological defect remains controversial. Lymphocytes from a child who had been thymectomized at birth responded normally to PHA, and a normal capacity for delayed hypersensitivity reactions was demonstrated by skin test and homograft rejection.
5例布鲁顿型无丙种球蛋白血症患者对植物血凝素（PHA）和抗原的淋巴细胞反应正常。1例胸腺发育不良婴儿的淋巴细胞对PHA无反应。3例共济失调毛细血管扩张症患者对PHA和抗原的反应各不相同。这些患者的淋巴细胞反应似乎反映了胸腺依赖性细胞免疫状态或迟发型超敏反应能力。2例维斯科特-奥尔德里奇综合征患儿（一种免疫缺陷仍存在争议的疾病）对PHA和抗原的淋巴细胞反应正常。1例出生时已行胸腺切除术的儿童的淋巴细胞对PHA反应正常，皮肤试验和同种异体移植排斥反应证明其具有正常的迟发型超敏反应能力。
