Thomas H C, Ferguson A, McLennan J G, Mason D K
J Clin Pathol. 1973 May;26(5):371-4. doi: 10.1136/jcp.26.5.371.
We have investigated the incidence of antibodies to food antigens in patients with recurrent minor aphthous ulceration and in patients with other oral ulcerative diseases. The incidence of these antibodies was the same in both groups of patients and was significantly greater than the incidence in a control group of normal people. There was no evidence to support the hypothesis that aphthous ulceration is primarily due to hypersensitivity to food antigens. The factors which might contribute to the absorption of antigenic molecules from the mouth and to the increased immune response in patients with oral disease have been considered.
我们调查了复发性轻型阿弗他溃疡患者以及其他口腔溃疡性疾病患者体内食物抗原抗体的发生率。这两组患者中这些抗体的发生率相同,且显著高于正常对照组人群的发生率。没有证据支持阿弗他溃疡主要是由于对食物抗原过敏的假说。我们已经考虑了可能导致口腔内抗原分子吸收以及口腔疾病患者免疫反应增强的因素。