Ekström J, Elmér M
Scand J Urol Nephrol. 1983;17(2):145-8. doi: 10.3109/00365598309180158.
The circular muscle activity of the urethra of the male rat was isometrically measured in vitro in response to noradrenaline, phenylephrine and isoprenaline. The urethra was found to be supplied with both alpha- and beta-adrenoceptors mediating contraction and relaxation, respectively. The substance 6-hydroxydopamine is known to cause a selective destruction of adrenergic nerves. In the present study 6-hydroxydopamine (100 mg/kg) was injected intravenously into a group of rats twice with a weekly interval. When the urethra was examined 2-3 weeks after the first injection a supersensitivity mediated both via alpha- and beta-adrenoceptors was found to have developed, suggesting that the urethra of the male rat normally is under the influence of adrenergic activity. The findings are discussed in relation to denervation supersensitivity of the neurogenic bladder in man.
在体外等长测量雄性大鼠尿道环形肌对去甲肾上腺素、去氧肾上腺素和异丙肾上腺素的反应。发现尿道同时具有分别介导收缩和舒张的α-和β-肾上腺素能受体。已知6-羟基多巴胺可导致肾上腺素能神经的选择性破坏。在本研究中，对一组大鼠静脉注射6-羟基多巴胺（100mg/kg），每周一次，共注射两次。在首次注射后2-3周检查尿道时，发现通过α-和β-肾上腺素能受体介导的超敏反应均已出现，这表明雄性大鼠的尿道通常受肾上腺素能活动的影响。结合人类神经源性膀胱的去神经超敏反应对这些发现进行了讨论。
