Agostoni A, Berfasconi C, Gerli G C, Luzzana M, Rossi-Bernardi L
Science. 1973 Oct 19;182(4109):300-1. doi: 10.1126/science.182.4109.300.
Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs-Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red cell, causing a decreased oxygen affinity of hemoglobin according to the classical Bohr effect. No release of 2,3-diphosphoglycerate which may be bound to the membrane is thus necessary to explain the effect of propranolol on the oxygen dissociation curve of blood.
普萘洛尔会导致红细胞中钾离子大量泄漏，这会导致红细胞膜两侧的吉布斯-唐南平衡发生改变。根据这一机制，普萘洛尔的存在会显著增加红细胞内部的氢离子活性，根据经典的玻尔效应，导致血红蛋白的氧亲和力降低。因此，无需释放可能与膜结合的2,3-二磷酸甘油酸来解释普萘洛尔对血液氧解离曲线的影响。
