血清介导的AKR小鼠白血病细胞破坏
Serum-mediated leukemia cell destruction in AKR mice.
作者信息
Kassel R L, Old L J, Carswell E A, Fiore N C, Hardy W D
出版信息
J Exp Med. 1973 Oct 1;138(4):925-38. doi: 10.1084/jem.138.4.925.
Abstract
AKR mice with spontaneous leukemia were infused with normal serum from a variety of species. Leukemia cell destruction was produced by serum from strains of mice possessing the full spectrum of complement components, but not by serum from strains with a genetically determined deficiency of C5. Serum from guinea pigs, horses, and humans also causes destruction of leukemia cells. The antileukemic factor in normal serum was heat labile (56 degrees C for 35 min) and could be inactivated by cobra venom factor (CVF). Tests of individual complement factors from guinea pig serum and from human serum suggest that C5 is the antileukemic complement component in normal serum. Evidence was obtained that complement also plays a role in the antileukemic effect of interferon and endotoxin.
摘要
将患有自发性白血病的AKR小鼠输注来自多种物种的正常血清。具有全套补体成分的小鼠品系的血清可导致白血病细胞破坏，但基因决定缺乏C5的品系的血清则不能。豚鼠、马和人类的血清也会导致白血病细胞破坏。正常血清中的抗白血病因子对热不稳定（56摄氏度，35分钟），可被眼镜蛇毒因子（CVF）灭活。对豚鼠血清和人血清中单个补体因子的测试表明，C5是正常血清中的抗白血病补体成分。有证据表明，补体在干扰素和内毒素的抗白血病作用中也起作用。
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