Agnantis N T, Rosen P P
Am J Clin Pathol. 1979 Sep;72(3):383-9. doi: 10.1093/ajcp/72.3.383.
Eight cases of a rare, distinctive variant of infiltrating mammary carcinoma featuring benign multinucleated osteoclast-like giant cells are reported. The multinucleated osteoclast-like giant cells are reported. The multinucleated giant cells were associated with ductal carcinoma in five cases and with infiltrating lobular carcinoma in three cases. Although three patients had lymph nodal metastases in level one, none of the nodal metastases contained giant cells. From the limited follow-up data of this report, it seems likely that the prognosis for patients who have this type of adenocarcinoma is not especially favorable. The observation that the giant cells generally occurred in areas of prominent angiogenesis suggests that the angiogenesis may be induced by some chemical substance produced by the tumor cells. Biochemical and immunologic investigations may eventually provide an explanation for this unusual morphologic manifestation of host reaction to mammary carcinoma.
报告了8例浸润性乳腺癌的罕见、独特变体，其特征为良性多核破骨细胞样巨细胞。报告了多核破骨细胞样巨细胞。5例多核巨细胞与导管癌相关，3例与浸润性小叶癌相关。虽然3例患者有一级淋巴结转移，但转移淋巴结中均未含巨细胞。根据本报告有限的随访数据，患有这种类型腺癌的患者预后似乎不太乐观。巨细胞通常出现在血管生成显著的区域这一观察结果表明，血管生成可能是由肿瘤细胞产生的某种化学物质诱导的。生化和免疫学研究最终可能会为这种宿主对乳腺癌的异常形态学表现提供解释。
