交感神经支配在控制犊牛血浆胰高血糖素浓度中的作用。

The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf.

Bloom S R, Edwards A V, Vaughan N J

J Physiol. 1973 Sep;233(2):457-66. doi: 10.1113/jphysiol.1973.sp010317.

Abstract

The extent to which the splanchnic sympathetic innervation is implicated in the control of plasma glucagon concentration has been investigated in the young calf.2. Stimulation of the peripheral ends of both splanchnic nerves (0.5-10.0 c/s for 10 min) caused an abrupt increase in plasma glucagon concentration in adrenalectomized calves 3-5 weeks after birth. This effect was found to be statistically significant (P < 0.01) at each of these frequencies. In calves tested during the first 24 hr after birth comparatively small responses were obtained.3. The hyperglycaemia produced by splanchnic nerve stimulation in older calves caused an abrupt rise in plasma insulin concentration when stimulation was discontinued but insulin release was completely inhibited throughout the period of stimulation at all frequencies tested.4. It is concluded that tonic changes in sympathetic efferent activity are likely to modify plasma glucagon concentration in the normal conscious calf.

摘要

在内脏交感神经支配与血浆胰高血糖素浓度控制之间的关联程度方面，已在幼犊身上展开了研究。
刺激双侧内脏神经的外周端（0.5 - 10.0次/秒，持续10分钟），导致出生3 - 5周的去肾上腺幼犊血浆胰高血糖素浓度急剧升高。在这些频率下，该效应均具有统计学显著性（P < 0.01）。在出生后最初24小时内进行测试的幼犊中，获得的反应相对较小。
在内脏神经刺激对年龄较大的幼犊产生的高血糖症，在刺激停止时导致血浆胰岛素浓度急剧上升，但在所有测试频率下，整个刺激期间胰岛素释放均被完全抑制。
得出的结论是，交感传出活动的紧张性变化可能会改变正常清醒幼犊的血浆胰高血糖素浓度。