清醒去肾上腺犊牛内脏神经外周端受刺激时胰腺的内分泌反应。
Pancreatic endocrine responses to stimulation of the peripheral ends of the splanchnic nerves in the conscious adrenalectomized calf.
作者信息
Bloom S R, Edwards A V
出版信息
J Physiol. 1980 Nov;308:39-48. doi: 10.1113/jphysiol.1980.sp013460.
Abstract
- Certain effects of stimulation of the peripheral ends of both splanchnic nerves have been investigated in unanaesthetized calves, given appropriate adrenal steroid replacement therapy. 2. Splanchnic nerve stimulation at frequencies within the physiological range produced prompt rises in the concentration of glucose, pancreatic glucagon and pancreatic polypeptide in the arterial plasma. These responses were followed by a rapid rise in plasma insulin concentration when the stimulus was terminated. The extent of this rise was related to the plasma glucose concentration at that precise point in time. 3. Stimulation at all frequencies tested had no effect on the concentration of vasoactive intestinal peptide in lymph collected from the intestinal duct. 4. The results are discussed in relation to those obtained in previous studies in anaesthetized calves of the same age.
摘要
- 在接受适当肾上腺类固醇替代疗法的未麻醉小牛中，对双侧内脏神经外周端刺激的某些效应进行了研究。2. 生理范围内频率的内脏神经刺激使动脉血浆中的葡萄糖、胰高血糖素和胰多肽浓度迅速升高。刺激终止后，血浆胰岛素浓度迅速上升。这种上升的程度与该精确时间点的血浆葡萄糖浓度有关。3. 所有测试频率的刺激对从肠导管收集的淋巴中的血管活性肠肽浓度均无影响。4. 结合先前在相同年龄麻醉小牛中获得的结果对这些结果进行了讨论。
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