Medeiros A A, O'Brien T F
Lancet. 1975 Mar 29;1(7909):716-9. doi: 10.1016/s0140-6736(75)91630-x.
Ampicillin-resistant Haemophilus influenzae type B have been reported only during the past year. Five clinical isolates from the U.S. and Germany all had the TEM-type beta-lactamase which is known to be transferred widely among other gram-negative bacilli. Unlike those bacilli, however, the H. influenzae cell had very little barrier to entry of penicillins. This greater permeability of the H. influenzae cell to penicillins appeared to reduce the protective effect of its beta-lactamase, in that acquisition of the TEM-type beta-lactamase increased levels of resistance to penicillins much less for individual cells of H. influenzae than for those of Escherichia coli. Large inocula of either species appeared highly resistant. The unusually low level of resistance of individual cells of H. influenzae containing the TEM-type beta-lactamase may have delayed their emergence or recognition, and has unresolved clinical implications.
仅在过去一年中才有关于耐氨苄西林的B型流感嗜血杆菌的报道。来自美国和德国的5株临床分离株均具有TEM型β-内酰胺酶，已知该酶可在其他革兰氏阴性杆菌中广泛传播。然而，与那些杆菌不同的是，流感嗜血杆菌细胞对青霉素的进入几乎没有屏障。流感嗜血杆菌细胞对青霉素的这种更高通透性似乎降低了其β-内酰胺酶的保护作用，因为获得TEM型β-内酰胺酶后，流感嗜血杆菌单个细胞对青霉素的耐药水平增加幅度远小于大肠杆菌单个细胞。两种菌的大量接种物似乎都具有高度耐药性。含有TEM型β-内酰胺酶的流感嗜血杆菌单个细胞耐药水平异常低，这可能延迟了它们的出现或识别，并且具有尚未解决的临床意义。
