Thornsberry C, Baker C N, Kirven L A, Swenson J M
Antimicrob Agents Chemother. 1976 Jan;9(1):70-3. doi: 10.1128/AAC.9.1.70.
Sixty-seven clinical isolates of Haemophilus influenzae from various sections of the United States, England, and Germany were tested for susceptibility to penicillin, ampicillin, amoxicillin, epicillin, carbenicillin, ticarcillin, and methicillin. Fifty-three of the strains had previously been judged to be ampicillin resistant and 14 had been determined to be ampicillin susceptible. Fifty-two of the 53 resistant strains produced beta-lactamase, but none of the susceptible strains produced it. On the basis of minimal inhibitory concentrations, the most active compounds were ticarcillin and carbenicillin. Whether this greater activity is useful clinically has not been established.
对来自美国、英国和德国不同地区的67株流感嗜血杆菌临床分离株进行了青霉素、氨苄西林、阿莫西林、依匹西林、羧苄西林、替卡西林和甲氧西林的药敏试验。其中53株菌株此前被判定为氨苄西林耐药，14株被判定为氨苄西林敏感。53株耐药菌株中有52株产生β-内酰胺酶，但敏感菌株均未产生。根据最低抑菌浓度，活性最强的化合物是替卡西林和羧苄西林。这种更高的活性在临床上是否有用尚未确定。
