饮用水中钠与妊娠中毒症关系的评估。
Evaluation of the relationship of sodium in drinking water and toxemia of pregnancy.
作者信息
Jones R F, Cech I I, Holguin A H, Hardy R J
出版信息
Am J Public Health. 1979 Sep;69(9):917-21. doi: 10.2105/ajph.69.9.917.
This study is a retrospective case comparison analysis of the relationship of water-borne Na+ and toxemia of pregnancy as a part of a continuous investigation at our facility on the role of various water constituents in human chronic disease. Five hundred thirty-seven toxemic pregnant women delivered at Jefferson Davis Hospital, Houston, Texas, during 1976 were matched by age, race, obstetrical history, and month of delivery to 537 non-toxemic controls. Sodium concentration in each patient's drinking water was derived, based on her address, from earlier prepared maps of sodium distribution in Houston's water supplies. Paired t-tests were performed to compare the Na+ levels, which varied from 19 to 250 mg/l in water supplies of cases and controls. Odds ratio analysis was used to test for the presence of a gradient in occurrence of toxemia in parallel with the gradient of Na+. No significant impact of water-borne Na+ in the indicated range was observed. Further studies incorporating still higher ranges are contemplated.
本研究是一项回顾性病例对照分析，旨在探讨水中钠含量与妊娠中毒症之间的关系，这是我们机构对各种水中成分在人类慢性病中作用的持续调查的一部分。1976年在得克萨斯州休斯敦杰斐逊·戴维斯医院分娩的537名妊娠中毒症孕妇，根据年龄、种族、产科病史和分娩月份，与537名非妊娠中毒症对照者进行匹配。根据每位患者的住址，从休斯敦供水系统钠分布的早期绘制地图中得出其饮用水中的钠浓度。进行配对t检验以比较病例组和对照组供水系统中钠含量水平，其范围为19至250毫克/升。采用优势比分析来检验妊娠中毒症发生率是否与钠含量梯度呈平行梯度。在所示范围内未观察到水中钠对妊娠中毒症有显著影响。考虑进一步开展纳入更高钠含量范围的研究。
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