5-氟胞嘧啶在肾功能受损患者中的应用。
Use of 5-fluorocytosine in patients with impaired renal function.
作者信息
Dawborn J K, Page M D, Schiavone D J
出版信息
Br Med J. 1973 Nov 17;4(5889):382-4. doi: 10.1136/bmj.4.5889.382.
Abstract
The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.
摘要
在正常受试者和肾功能受损患者中测定了5-氟胞嘧啶（5-FC）的血浆水平和消除情况。已证实肾衰竭时该药物的半衰期延长。5-FC的肾清除率约为肌酐清除率的75%，肾功能不全患者应相应调整药物剂量。
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