5-氟胞嘧啶的快速微生物学检测
Rapid microbiological assay for 5-fluorocytosine.
作者信息
Schiavone D J, Page M D, Dawborn J K
出版信息
Br Med J. 1973 Nov 17;4(5889):380-2. doi: 10.1136/bmj.4.5889.380.
Abstract
A microbiological assay was developed for 5-fluorocytosine based on inhibition by the drug of the fall in pH produced by Candida albicans in a synthetic liquid culture medium. Serum and urine levels of the drug could be measured reproducibly in four hours.
摘要
基于5-氟胞嘧啶对白色念珠菌在合成液体培养基中产生的pH下降的抑制作用，开发了一种针对该药物的微生物学测定法。该药物在血清和尿液中的水平可在4小时内重复测定。
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Rapid microbiological assay for 5-fluorocytosine.5-氟胞嘧啶的快速微生物学检测
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引用本文的文献
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Analysis of pH and buffer effects on flucytosine activity in broth dilution susceptibility testing of Candida albicans in two synthetic media.在两种合成培养基中对白色念珠菌进行肉汤稀释药敏试验时，pH值和缓冲液对氟胞嘧啶活性影响的分析
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Simple assay for 5-fluorocytosine in the presence of amphotericin B.在两性霉素B存在的情况下对5-氟胞嘧啶进行的简易检测
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本文引用的文献
1
The metabolism of 5-fluorocytosine-2-14-C and of cytosine-14-C in the rat and the disposition of 5-fluorocytosine-2-14-C in man.5-氟胞嘧啶-2-¹⁴C和胞嘧啶-¹⁴C在大鼠体内的代谢以及5-氟胞嘧啶-2-¹⁴C在人体内的分布。
Biochem Pharmacol. 1966 Apr;15(4):435-46. doi: 10.1016/0006-2952(66)90254-1.
2
In vitro studies with 5-fluorocytosine.5-氟胞嘧啶的体外研究。
Appl Microbiol. 1969 Jun;17(6):871-7. doi: 10.1128/am.17.6.871-877.1969.
3
The kinetics of 5-fluorocytosine elimination in man.
Aust N Z J Med. 1972 May;2(2):153-8. doi: 10.1111/j.1445-5994.1972.tb03925.x.
4
Rapid microbiological assay of antibiotic in blood and other body fluids.血液及其他体液中抗生素的快速微生物学检测
Lancet. 1968 Aug 17;2(7564):375-8. doi: 10.1016/s0140-6736(68)90593-x.
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