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从绿色青霉培养物中生产、分离和初步毒性研究短杆菌酰胺A。

Production, isolation, and preliminary toxicity studies of brevianamide A from cultures of Penicillium viridicatum.

作者信息

Wilson B J, Yang D T, Harris T M

出版信息

Appl Microbiol. 1973 Oct;26(4):633-5. doi: 10.1128/am.26.4.633-635.1973.

DOI:10.1128/am.26.4.633-635.1973
PMID:4751807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC379866/
Abstract

Brevianamide A, one of a novel group of alkaloids first obtained from Penicillium brevi-compactum, has also been isolated as a principal metabolite from two key isolates of P. viridicatum. Procedures for bioproduction and purification are described. This compound was not toxic when fed or injected into mice and had no antibiotic properties against several common bacterial and fungal microorganisms. Brevianamides A and B are among at least four yellow metabolites that may be formed by isolates of P. viridicatum.

摘要

短柄酰胺A是首次从短密青霉中获得的一组新型生物碱之一，它也从绿青霉的两个关键分离株中作为主要代谢产物被分离出来。文中描述了其生物生产和纯化的方法。该化合物经喂食或注射给小鼠时无毒，并且对几种常见的细菌和真菌微生物没有抗菌特性。短柄酰胺A和B是绿青霉分离株可能形成的至少四种黄色代谢产物中的两种。

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本文引用的文献

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