肾上腺素能β受体阻滞剂对精神应激、儿茶酚胺和运动时心率反应的不同影响。
Different effects of adrenergic beta-receptor blockade on heart rate response to mental stress, catecholamines, and exercise.
作者信息
Taylor S H, Meeran M K
出版信息
Br Med J. 1973 Nov 3;4(5887):257-9. doi: 10.1136/bmj.4.5887.257.
Abstract
The magnitude and duration of effect of a single 40-mg oral tablet of oxprenolol on the tachycardias associated with motor-car driving, isoprenaline infusion, and walking were compared against placebo in six normal people by a double-blind study. The tachycardias due to driving and isoprenaline were both conspicuousy reduced for over eight hours; the magnitude and duration of the reduction in exercise tachycardia was substantially less. Thus relatively small doses of beta-receptor antagonists will suppress the increase in heart rate induced by mental stress or catecholamines with relatively little effect on the response to everyday exercise. Possibly smaller doses of these drugs would relieve emotionally-induced anginal pain and tachycardia.
摘要
通过双盲研究，在6名正常人中将单次口服40毫克氧烯洛尔片剂对与驾驶汽车、输注异丙肾上腺素及步行相关的心动过速的作用强度和持续时间与安慰剂进行了比较。由驾驶和异丙肾上腺素引起的心动过速在8个多小时内均显著降低；运动性心动过速降低的幅度和持续时间则明显较短。因此，相对小剂量的β受体拮抗剂就能抑制精神应激或儿茶酚胺引起的心率增加，而对日常运动反应的影响相对较小。或许更小剂量的这些药物就能缓解情绪诱发的心绞痛和心动过速。
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Different effects of adrenergic beta-receptor blockade on heart rate response to mental stress, catecholamines, and exercise.肾上腺素能β受体阻滞剂对精神应激、儿茶酚胺和运动时心率反应的不同影响。
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本文引用的文献
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Electrocardiographic effects of isoprenaline in normal subjects and patients with coronary atherosclerosis.异丙肾上腺素对正常人和冠状动脉粥样硬化患者的心电图影响。
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