膳食纤维（麸皮）对胆汁盐代谢的改变。
Alteration of bile salt metabolism by dietary fibre (bran).
作者信息
Pomare E W, Heaton K W
出版信息
Br Med J. 1973 Nov 3;4(5887):262-4. doi: 10.1136/bmj.4.5887.262.
Abstract
Feeding dietary fibre in the form of bran induced changes in bile salt metabolism in five people with intact gall bladders. There was evidence of reduced dehydroxylation of bile salts; the proportion of deoxycholate conjugates in bile was reduced and the transfer of radioactivity from labelled taurocholate to deoxycholate was decreased. These findings, which were independent of changes in intestinal transit rate, imply that bran reduced the degradation of bile salts by colonic bacteria. This property of bran accords with recent theories that fibre-depleted diets favour the degradation of bile salts in the colon. These findings may be relevant to the aetiology of large bowel cancer.
摘要
给五名胆囊功能正常的人喂食麸皮形式的膳食纤维会引起胆汁盐代谢的变化。有证据表明胆汁盐的脱羟基作用减弱；胆汁中脱氧胆酸盐结合物的比例降低，放射性从标记的牛磺胆酸盐向脱氧胆酸盐的转移减少。这些与肠道转运速率变化无关的发现表明，麸皮减少了结肠细菌对胆汁盐的降解。麸皮的这一特性与最近的理论相符，即缺乏纤维的饮食有利于结肠中胆汁盐的降解。这些发现可能与大肠癌的病因学有关。
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本文引用的文献
1
The influence of diet on fecal lipids in South African white and Bantu prisoners.饮食对南非白人和班图族囚犯粪便脂质的影响。
Am J Clin Nutr. 1962 Aug;11:142-55. doi: 10.1093/ajcn/11.2.142.
2
Studies on the adsorption of bile salts to non-absorbed components of diet.关于胆汁盐对饮食中未吸收成分吸附作用的研究。
Biochim Biophys Acta. 1968 Jan 10;152(1):165-73. doi: 10.1016/0005-2760(68)90018-0.
3
Calorie conversion factors. An experimental reassessment of the factors used in the calculation of the energy value of human diets.卡路里转换系数。对用于计算人类饮食能量值的系数进行的实验性重新评估。
Br J Nutr. 1970 Jun;24(2):517-35. doi: 10.1079/bjn19700050.
4
Epidemiology of cancer of the colon and rectum.结肠直肠癌的流行病学
Cancer. 1971 Jul;28(1):3-13. doi: 10.1002/1097-0142(197107)28:1<3::aid-cncr2820280104>3.0.co;2-n.
5
Effect of dietary taurine on fecal bile salt excretion in rats and hamsters fed cholestyramine.日粮牛磺酸对喂食消胆胺的大鼠和仓鼠粪便胆盐排泄的影响。
Proc Soc Exp Biol Med. 1971 Dec;138(3):830-4. doi: 10.3181/00379727-138-36001.
6
Metabolism of steroid and amino acid moieties of conjugated bile acids in man. I. Cholylglycine.人体中结合胆汁酸的类固醇和氨基酸部分的代谢。I. 甘氨胆酸。
J Clin Invest. 1972 Jul;51(7):1889-97. doi: 10.1172/JCI106991.
7
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Nature. 1971 Aug 20;232(5312):554-5. doi: 10.1038/232554a0.
8
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Acta Pathol Microbiol Scand. 1968;72(2):313-29. doi: 10.1111/j.1699-0463.1968.tb01345.x.
9
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10
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