Ginsburg C M, McCracken G H
Antimicrob Agents Chemother. 1979 Jul;16(1):74-6. doi: 10.1128/AAC.16.1.74.
The pharmacokinetics of cephradine suspension were studied in 16 infants and children who were 13 months to 8 years and 3 months of age (means age, 3.5 years). Mean peak concentrations of 21.3 and 9.9 mug/ml were achieved at 30 min after administration of 60-mg/kg doses to fasting and nonfasting patients. The area under the serum concentration-time curve was 26% larger in fasting than in fed subjects. The half-life of cephradine in serum was 0.8 and 1.0 h in fasting and fed groups, respectively. Antimicrobial activity was detected in 49% of all salivary samples; in 75% of specimens, the concentrations were less than the 50% minimum inhibitory concentration for most pneumococci and group A streptococci. Urinary concentrations of cephradine ranged from 28 to 8,760 mug/ml and were independent of feeding status.
对16名年龄在13个月至8岁3个月（平均年龄3.5岁）的婴幼儿和儿童进行了头孢拉定混悬液的药代动力学研究。对空腹和非空腹患者给予60mg/kg剂量后，在30分钟时平均峰值浓度分别达到21.3和9.9μg/ml。空腹受试者血清浓度-时间曲线下面积比进食受试者大26%。头孢拉定在血清中的半衰期在空腹组和进食组分别为0.8小时和1.0小时。在所有唾液样本中，49%检测到抗菌活性；在75%的样本中，浓度低于大多数肺炎球菌和A组链球菌的50%最低抑菌浓度。头孢拉定的尿浓度范围为28至8760μg/ml，且与进食状态无关。
