可兴奋膜中钠通透性变化数学模型的物理解释。
The physical interpretation of mathematical models for sodium permeability changes in excitable membranes.
作者信息
Jakobsson E
出版信息
Biophys J. 1973 Nov;13(11):1200-11. doi: 10.1016/S0006-3495(73)86055-2.
Abstract
This paper deals with the physical interpretation of existing mathematical models which describe the transient sodium conductance changes in excitable membranes. It is shown that there are clear limitations to the specificity of inferences which may be drawn about physical mechanism from the behavior of abstract models. Within these limitations, it is shown that a pronounced inactivation shift is not necessarily evidence for coupling between the events responsible for the rise and inactivation of the sodium conductance, but that the inactivation shift may be associated with an event whose rate explicitly depends on the rate of continuous voltage change or magnitude of instantaneous voltage change.
摘要
本文探讨了描述可兴奋膜中瞬态钠电导变化的现有数学模型的物理解释。结果表明，从抽象模型的行为推断物理机制的特异性存在明显局限性。在这些局限性范围内，研究表明，明显的失活位移不一定是钠电导上升和失活相关事件之间耦合的证据，但是失活位移可能与一个速率明确依赖于连续电压变化速率或瞬时电压变化幅度的事件有关。
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