儿童营养不良时念珠菌清除功能缺陷。
Defective Candida killing in childhood malnutrition.
作者信息
Tuck R, Burke V, Gracey M, Malajczuk A
出版信息
Arch Dis Child. 1979 Jun;54(6):445-7. doi: 10.1136/adc.54.6.445.
This study shows that malnourished children have impaired candidacidal activity of leucocytes, a finding which runs parallel to the higher rates of isolation of Candida sp. from throat secretions. In well nournished subjects the mean candidacidal ability was 44.5% in the moderately undernourished group it was 17.6%, and in the severely malnourished group it was 13.7%. This impaired candidacidal capacity may be important in the establishment of large numbers of Candida sp. which are commonly found in the upper intestine and in the pathogenesis of diarrhoea in children with malnutrition.
本研究表明，营养不良的儿童白细胞杀念珠菌活性受损，这一发现与从咽喉分泌物中分离出念珠菌属的较高比率相一致。在营养良好的受试者中，平均杀念珠菌能力为44.5%；在中度营养不良组中为17.6%；在重度营养不良组中为13.7%。这种受损的杀念珠菌能力对于在小肠上部常见的大量念珠菌属的定植以及营养不良儿童腹泻的发病机制可能具有重要意义。
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