Campbell D G
Arch Ophthalmol. 1979 Sep;97(9):1667-72. doi: 10.1001/archopht.1979.01020020235011.
A new theory states that mechanical rubbing between anterior packets of zonules and the peripheral iris in predisposed eyes is the cause of the loss of iris pigment in pigmentary glaucoma and in the pigmentary dispersion syndrome. The peripheral radial defects were in close approximation to anterior packets. The total number of iris defects in advanced cases correlated with the average number of anterior packets. Histologic study showed a groove in the stroma of the iris as well as loss of the pigmented neuroepithelium and was compatible with mechanical damage. The theory explains why the disease predominates in young myopic men, why it decreases in incidence with age, and why, in some cases, it regresses. Treatment with an alpha-adrenergic blocking agent may be advantageous in this condition.
一种新理论认为，在易患眼内，小带前束与周边虹膜之间的机械摩擦是色素性青光眼和色素性分散综合征中虹膜色素丧失的原因。周边放射状缺损与小带前束紧密相邻。晚期病例中虹膜缺损的总数与小带前束的平均数量相关。组织学研究显示虹膜基质中有一条沟，同时色素性神经上皮缺失，这与机械损伤相符。该理论解释了为什么这种疾病在年轻近视男性中更为常见，为什么其发病率随年龄增长而降低，以及为什么在某些情况下会自行消退。在这种情况下，使用α-肾上腺素能阻滞剂进行治疗可能具有优势。
