Zheng Lingman, Liao Zhiyong, Zou Jian
Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou, China.
Eye Center of the Second Affiliated Hospital, Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Adv Ophthalmol Pract Res. 2024 Jun 5;4(4):173-181. doi: 10.1016/j.aopr.2024.06.001. eCollection 2024 Nov-Dec.
Myopia is one of the most common eye diseases globally, and has become an increasingly serious health concern among adolescents. Understanding the factors contributing to the onset of myopia and the strategies to slow its progression is critical to reducing its prevalence.
Animal models are key to understanding of the etiology of human diseases. Various experimental animal models have been developed to mimic human myopia, including chickens, rhesus monkeys, marmosets, mice, tree shrews, guinea pigs and zebrafish. Studies using these animal models have provided evidences and perspectives on the regulation of eye growth and refractive development. This review summarizes the characteristics of these models, the induction methods, common indicators of myopia in animal models, and recent findings on the pathogenic mechanism of myopia.
Investigations using experimental animal models have provided valuable information and insights into the pathogenic mechanisms of human myopia and its treatment strategies.
近视是全球最常见的眼部疾病之一，并且在青少年中已成为日益严重的健康问题。了解导致近视发病的因素以及减缓其进展的策略对于降低其患病率至关重要。
动物模型是理解人类疾病病因的关键。已经开发了各种实验动物模型来模拟人类近视，包括鸡、恒河猴、狨猴、小鼠、树鼩、豚鼠和斑马鱼。使用这些动物模型的研究为眼睛生长和屈光发育的调节提供了证据和观点。本综述总结了这些模型的特点、诱导方法、动物模型中近视的常见指标以及近视发病机制的最新研究结果。
使用实验动物模型的研究为人类近视的发病机制及其治疗策略提供了有价值的信息和见解。
