致癌亚硝基及相关化合物的作用机制。
The mechanisms of action of the carcinogenic nitroso and related compounds.
作者信息
Schoental R
出版信息
Br J Cancer. 1973 Nov;28(5):436-9. doi: 10.1038/bjc.1973.169.
Abstract
It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" and probably have become multifunctional. Their functional groups, being in close proximity, could ensure binding in a concerted manner with apposite reactive centres of chromatin to form a firm bridge, for example, between an amino group of nucleic acid base and thiols of protein chains.
摘要
有人认为，二烷基亚硝胺的直接致癌形式是它们的氧化产物，这些产物保留了烷基亚硝胺部分，但由于烷基的ω或β氧化而获得了羰基官能团。这类代谢产物类似于局部作用的致癌“亚硝酰胺”，可能已变成多功能的。它们的官能团彼此靠近，能够确保以协同方式与染色质的相应反应中心结合，例如在核酸碱基的氨基与蛋白质链的硫醇之间形成牢固的桥梁。
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