Payne R B, Little A J, Williams R B, Milner J R
Br Med J. 1973 Dec 15;4(5893):643-6. doi: 10.1136/bmj.4.5893.643.
Two hundred consecutive specimens received in this laboratory for "liver function tests" showed a wide range of abnormal protein concentrations. Calcium concentration correlated closely with albumin (r = 0.867) but less closely with total protein (r = 0.682). A simple formula for adjusting calcium concentration was derived from the regression equation of calcium on albumin. Adjusted calcium = calcium - albumin + 4.0, where calcium is in mg/100 ml and albumin in g/100 ml.Low calcium concentrations were found in 49 (24.5%) and raised concentrations in six (3%) of the 200 blood specimens taken for liver function tests. After adjustment, the 95% limits of the observed range were identical with the 95% limits of the normal range determined in this laboratory. Unlike adjustments based on total protein or specific gravity, the adjustment on albumin in 39 specimens which showed hypergammaglobulinaemia on electrophoresis gave normal calcium concentrations.
本实验室收到的200份连续送检用于“肝功能检查”的标本显示蛋白质浓度异常范围很广。钙浓度与白蛋白密切相关（r = 0.867），但与总蛋白的相关性稍弱（r = 0.682）。根据钙与白蛋白的回归方程得出了一个调整钙浓度的简单公式。校正钙 = 钙 - 白蛋白 + 4.0，其中钙的单位为mg/100 ml，白蛋白的单位为g/100 ml。在200份用于肝功能检查的血液标本中，49份（24.5%）钙浓度低，6份（3%）钙浓度高。调整后，观察范围的95%界限与本实验室确定的正常范围的95%界限相同。与基于总蛋白或比重的调整不同，对39份电泳显示高丙种球蛋白血症的标本进行白蛋白调整后，钙浓度正常。
