血浆钙随血浆比重、总蛋白和白蛋白的诱导变化而发生的变化。
Variation in plasma calcium with induced changes in plasma specific gravity, total protein, and albumin.
作者信息
Berry E M, Gupta M M, Turner S J, Burns R R
出版信息
Br Med J. 1973 Dec 15;4(5893):640-3. doi: 10.1136/bmj.4.5893.640.
Abstract
The relationship of plasma calcium levels to changes in plasma specific gravity, total protein, and albumin induced by venous stasis was investigated. Factors were derived for adjusting calcium results to offset the effects of variation in protein concentration and thus to make them of increased discriminatory value to the clinician. The validity of an existing specific gravity correction has been substantiated, but a more exact adjustment of 0.23 mg/100 ml of calcium for every 0.001 change in specific gravity is proposed. We recommend for automated laboratories that the factor based on albumin be used: 0.09 mg/100 ml of calcium should be subtracted from the total calcium value for every increase of 0.1 g in albumin above 4.6 g/100 ml, and a corresponding addition should be made for values of albumin below 4.6 g/100 ml.Using a calcium specific electrode, it has been shown that the ionized calcium concentration does not alter with prolonged venous stasis.
摘要
研究了血浆钙水平与静脉淤滞引起的血浆比重、总蛋白和白蛋白变化之间的关系。推导了用于调整钙结果的因子，以抵消蛋白质浓度变化的影响，从而使其对临床医生具有更高的鉴别价值。现有的比重校正的有效性已得到证实，但建议每0.001比重变化对钙进行更精确的调整，即每0.001比重变化调整0.23mg/100ml钙。对于自动化实验室，我们建议使用基于白蛋白的因子：白蛋白高于4.6g/100ml时，每增加0.1g白蛋白，应从总钙值中减去0.09mg/100ml钙；白蛋白低于4.6g/100ml时，应进行相应的添加。使用钙特异性电极已表明，长时间静脉淤滞不会改变离子钙浓度。
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本文引用的文献
1
RELATION OF SERUM CALCIUM TO SERUM ALBUMIN AND GLOBULINS.血清钙与血清白蛋白及球蛋白的关系
J Clin Invest. 1937 Nov;16(6):903-19. doi: 10.1172/JCI100917.
2
Ultrafiltration studies on calcium and phosphorus in human serum.人体血清中钙和磷的超滤研究。
Bull Johns Hopkins Hosp. 1952 Jul;91(1):1-21.
3
The determination of protein-bound calcium and magnesium by ultrafiltration-in-vivo with special reference to terminology and method.通过体内超滤法测定蛋白质结合钙和镁，特别涉及术语和方法。
Clin Chim Acta. 1961 Jul;6:550-65. doi: 10.1016/0009-8981(61)90147-4.
4
NOMOGRAM FOR ESTIMATING DIFFUSIBLE SERUM CALCIUM.估算可扩散血清钙的列线图
Clin Chem. 1964 Mar;10:235-40.
5
Ultracentrifugal analysis of protein-bound and free calcium in human serum.人血清中蛋白质结合钙和游离钙的超速离心分析
J Biol Chem. 1960 Dec;235:3654-8.
6
The ionized, complexed, and protein-bound fractions of calcium in plasma; an investigation of patients with various diseases which affect calcium metabolism, with an additional study of the role of calcium ions in the prevention of tetany.血浆中钙的离子化、络合及与蛋白质结合部分；对影响钙代谢的各种疾病患者的调查，以及对钙离子在预防手足搐搦中作用的补充研究。
Q J Med. 1958 Oct;27(108):463-94.
7
The ultrafiltrable calcium of human serum. I. Ultrafiltration methods and normal values.人血清中的可超滤钙。I. 超滤方法及正常值。
J Clin Invest. 1957 May;36(5):738-48. doi: 10.1172/JCI103477.
8
Albumin as an aid to the interpretation of serum calcium.白蛋白辅助血清钙的解读。
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9
Studies with ion exchange calcium electrodes. 3. The state of serum calcium in patients with cirrhosis.离子交换钙电极的研究。3. 肝硬化患者的血清钙状态。
Gastroenterology. 1971 Jan;60(1):43-54.
10
On the cause and degree of intraindividual serum calcium variability.关于个体内血清钙变异性的原因及程度。
Scand J Clin Lab Invest. 1972 Oct;30(2):191-9. doi: 10.3109/00365517209081110.
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