微小棒状杆菌注射小鼠腹腔单核吞噬细胞的超微结构研究
An ultrastructural study of peritoneal mononuclear phagocytes from Corynebacterium parvum-injected mice.
作者信息
Pugh-Humphreys R G, Thomson A W
出版信息
Br J Exp Pathol. 1979 Jun;60(3):259-68.
Abstract
Peritoneal mononuclear phagocytes harvested from mice 24 h after i.p. injection of C. parvum displayed hypertrophy of the Golgi and smooth endoplasmic reticulum complex with attendant increase in lysosome production. The ingested bacilli were identified within phagolysosomes, within which large myelin figures accumulated. In addition to heterophagic vacuoles, autophagosomes and lipid droplets were observed. These latter two inclusions may reflect a direct or indirect cytopathic effect of C. parvum on the phagocytes.
摘要
腹腔注射微小隐孢子虫24小时后从小鼠体内收获的腹腔单核吞噬细胞显示高尔基体和平滑内质网复合体肥大，伴随溶酶体产生增加。在吞噬溶酶体内可识别出摄入的杆菌，其中积累了大量髓鞘样结构。除了异噬泡外，还观察到自噬体和脂滴。后两种内含物可能反映了微小隐孢子虫对吞噬细胞的直接或间接细胞病变效应。
相似文献
1
An ultrastructural study of peritoneal mononuclear phagocytes from Corynebacterium parvum-injected mice.
Br J Exp Pathol. 1979 Jun;60(3):259-68.
2
An ultrastructural study of peritoneal mononuclear phagocytes from iota carrageenan injected mice.
Cytobios. 1979;24(95 96):211-8.
3
Comparison of the in-vitro antitumor activity of peritoneal cells from mice injected with Corynebacterium parvum and Corynebacterium liquefaciens.
Hiroshima J Med Sci. 1979 Jun;28(2):95-101.
4
The distribution and persistence in vivo of Corynebacterium parvum in relation to its antitumor activity.
Cancer Res. 1977 Jun;37(6):1673-9.
5
[Passive transfer of "Corynebacterium parvum" anti-tumour protection by stimulated peritoneal cells ].
Ann Immunol (Paris). 1981 Jul-Aug;132D(1):43-54.
6
7
8
9
[Anti-tumour cytostatic and cytotoxic properties of peritoneal exudate cells of conventional and germ-free mice, stimulated or not by "Corynebacterium parvum" (author's transl)].
Ann Immunol (Paris). 1982 Jan-Feb;133C(1):33-43.
10
Lysosomes and the "toxicity" of Rickettsias. VI. In vivo response of mouse peritoneal phagocytes to L-cell-grown Chlamydia psittaci 6BC strain.
Can J Microbiol. 1975 Mar;21(3):323-31. doi: 10.1139/m75-046.
引用本文的文献
1
Inhibition by the Landschütz ascites carcinoma of the granulomatous inflammatory response to C. parvum.
Br J Cancer. 1982 Apr;45(4):598-612. doi: 10.1038/bjc.1982.97.
本文引用的文献
1
[STIMULATION OF THE PHAGOCYTIC ACTIVITY OF THE RETICULOENDOTHELIAL SYSTEM BY CORYNEBACTERIUM PARVUM].
J Reticuloendothel Soc. 1964 Jan;1:77-96.
2
Formation of myeloid bodies in rat liver lysosomes after chloroquine administration.
Exp Mol Pathol. 1968 Oct;9(2):212-29. doi: 10.1016/0014-4800(68)90037-3.
3
Mode of action of adjuvants: retinol and other lysosome-labilizing agents as adjuvants.
J Immunol. 1970 Jan;104(1):119-27.
4
Ultrastructure of human leukocytes after simultaneous fixation with glutaraldehyde and osmium tetroxide and "postfixation" in uranyl acetate.
J Cell Biol. 1968 Sep;38(3):615-27. doi: 10.1083/jcb.38.3.615.
5
In vitro inhibition of tumour cell growth and DNA synthesis by peritoneal and lung macrophages from mice injected with Corynebacterium parvum.
Int J Cancer. 1974 Apr 15;13(4):478-88. doi: 10.1002/ijc.2910130406.
6
Increased phagocytic cell activity and anaemia in Corynebacterium parvum treated mice.
Br J Exp Pathol. 1974 Feb;55(1):38-46.
7
Biological effects of Corynebacterium parvum. IV. Adjuvant and inhibitory activities on B lymphocytes.
Cell Immunol. 1973 May;7(2):290-301. doi: 10.1016/0008-8749(73)90251-7.
8
9
Chemistry and reaction mechanisms of complement.
Adv Immunol. 1968;8:1-80. doi: 10.1016/s0065-2776(08)60464-2.
10
Enhancement and depression of the antibody response in mice caused by Corynebacterium parvum.
Clin Exp Immunol. 1974 Jul;17(3):519-32.
Zotero 插件