Dias P L
Br J Ophthalmol. 1979 Aug;63(8):574-7. doi: 10.1136/bjo.63.8.574.
An analysis of the lactic acid dehydrogenase (LDH) activity in the aqueous humour of 24 enucleated eyes with retinoblastoma showed that though there was no relationship between the LDH levels and the age of the patient, there appeared to be an increase in the LDH activity with increase in the duration of the tumour. Undifferentiated tumour cells and tumour cell necrosis seemed to contribute to an increase of LDH levels in the aqueous humour, but there was no relationship between the occurrence of calcification and the LDH secretion into the aqueous humour. Massive cell necrosis caused by radiotherapy and central retinal artery occlusion significantly increased the LDH levels in the aqueous. It also appeared that recurrence was common after external cobalt therapy and that secondary extension of the tumour into the optic nerve and choroid was favoured by this procedure.
对24只患有视网膜母细胞瘤的摘除眼球房水中乳酸脱氢酶（LDH）活性的分析表明，尽管LDH水平与患者年龄之间没有关系，但随着肿瘤病程的延长，LDH活性似乎有所增加。未分化的肿瘤细胞和肿瘤细胞坏死似乎导致房水中LDH水平升高，但钙化的发生与房水中LDH分泌之间没有关系。放疗和视网膜中央动脉阻塞引起的大量细胞坏死显著增加了房水中的LDH水平。还发现钴外照射治疗后复发很常见，并且该治疗方法有利于肿瘤向视神经和脉络膜的继发性扩展。
