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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Miller B G, Otto W R, Grimble R F, York D A, Taylor T G

Br J Nutr. 1979 Sep;42(2):185-99. doi: 10.1079/bjn19790106.

Groups of lean and genetically obese (ob/ob) mice were adapted to varying energy intakes and the rates of total protein turnover in liver, gut and kidney were measured. 2. Lean mice gained less weight when fed above maintenance and lost less weight when fed below maintance than obese mice. 3. Hepatic protein turnover (mg/d) was sigmoidally related to digestible energy intake in lean mice but showed no significant changes with dietary intake in obese mice. 4. The changes in protein turnover resulted from changes in both the half-lives of protein synthesis and catabolism and in tissue protein content. 5. In the lean mice, protein turnover in kidney and gut was not significantly changed with increasing energy intake until the highest level was reached. 6. The findings suggest that protein turnover may be an important cycle for the regulation of energy balance in mice and that this cycle is impaired in the genetically obese (ob/ob) mice.

将瘦小鼠和遗传性肥胖（ob/ob）小鼠分为不同组，使其适应不同的能量摄入量，并测量肝脏、肠道和肾脏中总蛋白质周转率。2. 与肥胖小鼠相比，瘦小鼠在高于维持量喂养时体重增加较少，在低于维持量喂养时体重减轻较少。3. 瘦小鼠肝脏蛋白质周转率（毫克/天）与可消化能量摄入量呈S形相关，但肥胖小鼠的蛋白质周转率随饮食摄入量无显著变化。4. 蛋白质周转率的变化是由蛋白质合成和分解代谢的半衰期以及组织蛋白质含量的变化引起的。5. 在瘦小鼠中，直到达到最高能量摄入水平，肾脏和肠道中的蛋白质周转率才随着能量摄入的增加而显著变化。6. 研究结果表明，蛋白质周转可能是调节小鼠能量平衡的一个重要循环，并且这个循环在遗传性肥胖（ob/ob）小鼠中受损。

Miller B G, Otto W R, Grimble R F, York D A, Taylor T G

Br J Nutr. 1979 Sep;42(2):185-99. doi: 10.1079/bjn19790106.

Groups of lean and genetically obese (ob/ob) mice were adapted to varying energy intakes and the rates of total protein turnover in liver, gut and kidney were measured. 2. Lean mice gained less weight when fed above maintenance and lost less weight when fed below maintance than obese mice. 3. Hepatic protein turnover (mg/d) was sigmoidally related to digestible energy intake in lean mice but showed no significant changes with dietary intake in obese mice. 4. The changes in protein turnover resulted from changes in both the half-lives of protein synthesis and catabolism and in tissue protein content. 5. In the lean mice, protein turnover in kidney and gut was not significantly changed with increasing energy intake until the highest level was reached. 6. The findings suggest that protein turnover may be an important cycle for the regulation of energy balance in mice and that this cycle is impaired in the genetically obese (ob/ob) mice.

将瘦小鼠和遗传性肥胖（ob/ob）小鼠分为不同组，使其适应不同的能量摄入量，并测量肝脏、肠道和肾脏中总蛋白质周转率。2. 与肥胖小鼠相比，瘦小鼠在高于维持量喂养时体重增加较少，在低于维持量喂养时体重减轻较少。3. 瘦小鼠肝脏蛋白质周转率（毫克/天）与可消化能量摄入量呈S形相关，但肥胖小鼠的蛋白质周转率随饮食摄入量无显著变化。4. 蛋白质周转率的变化是由蛋白质合成和分解代谢的半衰期以及组织蛋白质含量的变化引起的。5. 在瘦小鼠中，直到达到最高能量摄入水平，肾脏和肠道中的蛋白质周转率才随着能量摄入的增加而显著变化。6. 研究结果表明，蛋白质周转可能是调节小鼠能量平衡的一个重要循环，并且这个循环在遗传性肥胖（ob/ob）小鼠中受损。