通过31P核磁共振和冷冻蚀刻电子显微镜观察到脂质双层中脂质颗粒的出现。
The occurrence of lipidic particles in lipid bilayers as seen by 31P NMR and freeze-fracture electron-microscopy.
作者信息
de Kruijff B, Verkley A J, van Echteld C J, Gerritsen W J, Mombers C, Noordam P C, de Gier J
出版信息
Biochim Biophys Acta. 1979 Aug 7;555(2):200-9. doi: 10.1016/0005-2736(79)90160-3.
A new type of lipid organization is observed in mixtures of phosphatidyl-choline with cardiolipin (in the presence of Ca2+), monoglycosyldiglyceride and phosphatidylethanolamine (in the presence of cholesterol). This phase is characterised by an isotropic 31P NMR signal and is visualised by freeze-fracturing as particles and pits on the fracture faces of the lipid bilayer. As the most favourable model for this phase we propose the inverted micelle sandwiched in between the two monolayers of the lipid bilayer.
在磷脂酰胆碱与心磷脂（存在Ca2+）、单糖基甘油二酯和磷脂酰乙醇胺（存在胆固醇）的混合物中观察到一种新型脂质结构。该相的特征是具有各向同性的31P NMR信号，通过冷冻断裂在脂质双分子层的断裂面上呈现为颗粒和凹坑。作为该相最有利的模型，我们提出了夹在脂质双分子层两个单分子层之间的反胶束。
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