Ca2+诱导的磷脂酰胆碱-心磷脂双层膜中的各向同性运动和磷脂酰胆碱翻转
Ca2+-induced isotropic motion and phosphatidylcholine flip-flop in phosphatidylcholine-cardiolipin bilayers.
作者信息
Gerritsen W J, de Kruijff B, Verkleij A J, de Gier J, van Deenen L L
出版信息
Biochim Biophys Acta. 1980 Jun 6;598(3):554-60. doi: 10.1016/0005-2736(80)90035-8.
PMID:7388023
Abstract
Ca2+ induces a structural change in phosphatidylcholine-cardiolipin bilayers, which is visualised by freeze-fracturing as lipidic particles associated with the bilayer and is detected by 31P-NMR as isotropic motion of the phospholipids. In this structure a rapid transbilayer movement of phosphatidylcholine and a highly increased permeability towards Mn2+ are observed.
摘要
钙离子可诱导磷脂酰胆碱 - 心磷脂双层膜发生结构变化，这种变化通过冷冻断裂可观察到，表现为与双层膜相关的脂质颗粒，并且通过31P - NMR检测到磷脂的各向同性运动。在这种结构中，观察到磷脂酰胆碱的快速跨膜运动以及对锰离子的通透性显著增加。
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