Offeman R D, Williams M C
Biomater Med Devices Artif Organs. 1979;7(3):359-91. doi: 10.3109/10731197909119386.
A rotating-disk apparatus for shearing blood was employed to compare 22 materials for their tendency to cause hemolysis during standardized low-stress (130 dynes/cm2 maximum) laminar flow conditions. Rigid plastics, hydrogels, and carbons were among the materials tested. Time-independent ranking of the materials was possible for 75% of the data; these rankings correlated linearly (for polymers) with the critical surface tension gammac over the range 20--46 dyne/cm, with low gammac being associated with low hemolysis. Surface morphology was also found to influence hemolysis. Roughness in the 1--15 micron range had a distinct effect on hemolysis kinetics for polyethylene surfaces. This suggest that failure to find time-independence in 25% of the material rankings can be attributed to inadequate control of the roughness variable. It also emphasizes the importance of surface morphology, as well as surface chemistry, as a biocompatibility parameter.
采用一种用于剪切血液的旋转圆盘装置，在标准化的低应力（最大130达因/平方厘米）层流条件下，比较22种材料引起溶血的倾向。测试的材料包括硬质塑料、水凝胶和碳。75%的数据能够对材料进行与时间无关的排名；对于聚合物，这些排名与20-46达因/平方厘米范围内的临界表面张力γc呈线性相关，γc值低与溶血程度低相关。还发现表面形态会影响溶血。1-15微米范围内的粗糙度对聚乙烯表面的溶血动力学有显著影响。这表明，在25%的材料排名中未能发现与时间无关的情况可归因于对粗糙度变量的控制不足。这也强调了表面形态以及表面化学作为生物相容性参数的重要性。
