恶性肿瘤中的白细胞碱性磷酸酶

Leukocyte alkaline phosphatase in malignancies.

作者信息

Ho A D, Hunstein W, Dörken B, Pfreundschuh M, Kaufmann M, Krüger C

出版信息

Blut. 1979 Aug;39(2):141-5. doi: 10.1007/BF01008089.

Abstract

The leukocyte alklaine phosphatase (LAP) levels were determined in 183 patients with malignant diseases and 71 normal controls. The median LAP scores were 64 units (range 0 to 290) for the patients and 55 (range 2 to 158) for the controls, respectively, and no significant difference could be established. When analyzed according to primary malignancy, only in patients with Hodgkin's disease (n = 14) was the median value higher than normal (p less than 0.001). In patients with distant metastases (n = 48), higher LAP levels were demonstrated (M = 76, range 21 to 290) as compared to patients with no evidence of metastases (M = 53, range 0 to 229), (p less than 0.01). Thus, LAP activity has very limited value in the diagnosis of malignancies. Its elevation in the presence of malignant disease might, however, indicate metastases.

摘要

对183例恶性疾病患者和71名正常对照者测定了白细胞碱性磷酸酶（LAP）水平。患者的LAP评分中位数为64单位（范围0至290），对照者为55（范围2至158），两者无显著差异。按原发性恶性肿瘤分析时，仅霍奇金病患者（n = 14）的中位数高于正常（p < 0.001）。有远处转移的患者（n = 48）显示LAP水平较高（M = 76，范围21至290），而无转移证据的患者（M = 53，范围0至229）则较低（p < 0.01）。因此，LAP活性在恶性肿瘤诊断中的价值非常有限。然而，在存在恶性疾病时其升高可能提示转移。