Lokich J J
Cancer. 1977 Sep;40(3):1202-5. doi: 10.1002/1097-0142(197709)40:3<1202::aid-cncr2820400333>3.0.co;2-d.
One hundred patients with malignant disease were screened for leukocyte alkaline phosphate (LAP) activity. The new observation made was that patients with malignant disease demonstrate significantly lower levels of LAP than in normal controls. The low LAP activity is present irrespective of primary tumor category, "activity" of disease, or type of therapy. The pattern of metastases may influence LAP activity, in that patients with liver metastases tended to have higher LAP levels. In spite of low baseline LAP levels in patients with malignant disease, the development of secondary infection is associated with elevated LAP levels.
对100例恶性疾病患者进行了白细胞碱性磷酸酶（LAP）活性筛查。新的观察结果是，恶性疾病患者的LAP水平明显低于正常对照组。无论原发性肿瘤类别、疾病“活性”或治疗类型如何，均存在LAP活性低的情况。转移模式可能会影响LAP活性，因为有肝转移的患者往往LAP水平较高。尽管恶性疾病患者的基线LAP水平较低，但继发感染的发生与LAP水平升高有关。
