Purves E C, Playfair J H
Clin Exp Immunol. 1973 Sep;15(1):113-22.
Splenic PFC dose-response curves were measured in normal mice and in mice of the autoimmune NZB strain for the thymus-independent antigens pneumococcal polysaccharide type 3 (SIII) and bacterial levan. There were differences between the strains in the maximal response achieved to each antigen, but the level at which high dose tolerance occurred was the same in all the strains. The splenic anti-sheep erythrocyte plaque-forming cell dose-response curve of lethally-irradiated, bone marrow restored NZB mice was compared with that of (C57/B1 × BALB/c)F hybrid and (NZB × BALB/c)F hybrid mice. Although the dose-response curves of the two hybrid stains were less sharp than that of the NZB, the peak response occurred at the same dose of SRBC (10, i.v.), and reached the same level, tailing off at higher doses. These results indicate that the B cells of NZB mice display normal high-dose tolerance characteristics, at least to these three antigens.
在正常小鼠和自身免疫性NZB品系小鼠中，测定了对胸腺非依赖性抗原3型肺炎球菌多糖（SIII）和细菌左聚糖的脾PFC剂量反应曲线。各品系对每种抗原所达到的最大反应存在差异，但高剂量耐受发生的水平在所有品系中是相同的。将致死性照射、骨髓重建的NZB小鼠的脾抗绵羊红细胞空斑形成细胞剂量反应曲线与（C57/B1×BALB/c）F杂种小鼠和（NZB×BALB/c）F杂种小鼠的进行比较。虽然两个杂种品系的剂量反应曲线不如NZB的尖锐，但峰值反应在相同剂量的SRBC（10，静脉注射）时出现，并达到相同水平，在更高剂量时下降。这些结果表明，NZB小鼠的B细胞至少对这三种抗原表现出正常的高剂量耐受特性。
