Stephens R J, Freeman G, Stara J F, Coffin D L
Am J Pathol. 1973 Dec;73(3):711-26.
Beagle dogs exposed for 8 hours a day to 3 ppm O(3) for 18 months showed cytologic changes that indicate metabolic alterations. The endoplasmic reticulum of the type 2 alveolar epithelial cells in the proximal alveoli were frequently dilated and contained a moderately electron-dense substance having a periodicity of approximately 754 A. This condition was accompanied by a substantial reduction in the lamellar membranes in the characteristic lamellar bodies of the type 2 cells, suggesting a sequestering of protein in the endoplasmic reticulum. In addition, endothelial cells contained paracrystalline arrays of cytoplasmic membranes not observed in control animals.
每天暴露于3 ppm臭氧8小时，持续18个月的比格犬出现了表明代谢改变的细胞学变化。近端肺泡中2型肺泡上皮细胞的内质网经常扩张，含有一种中等电子密度的物质，其周期约为754埃。这种情况伴随着2型细胞特征性板层小体中板层膜的大量减少，提示蛋白质在内质网中被隔离。此外，内皮细胞含有对照动物中未观察到的细胞质膜的平行晶体排列。
