Lehnert S
Cell Tissue Kinet. 1979 May;12(3):239-48. doi: 10.1111/j.1365-2184.1979.tb00146.x.
Changes in the kinetics of the intestinal epithelium were observed in mice maintained on an elemental diet containing hydrolysed protein and medium chain triglycerides. An increase in the length of the villi seen shortly after commencement of the diet was followed by a reduction in the rate of proliferation in the crypt. After 7 days on the diet, an equilibrium state was reached with the cellularity of the villi being 120% that of control while the number of proliferative cells/crypt was reduced by 35%. The proliferative response of the crypt following irradiation occurred 16 hr later in diet-fed mice than in controls. It was postulated that, because of the increased cellularity of the villus compartment in diet-fed mice, additional time was required to reduce the number of villus cells to a critical level at which a proliferative response is induced in the crypt.
在喂食含水解蛋白和中链甘油三酯的要素饮食的小鼠中，观察到肠道上皮动力学的变化。饮食开始后不久可见绒毛长度增加，随后隐窝增殖速率降低。饮食7天后，达到平衡状态，绒毛细胞数量为对照组的120%，而每个隐窝增殖细胞数量减少35%。照射后，喂食饮食的小鼠隐窝的增殖反应比对照组晚16小时出现。据推测，由于喂食饮食的小鼠绒毛区细胞数量增加，需要额外的时间将绒毛细胞数量减少到临界水平，此时会在隐窝中诱导增殖反应。
