Kovacs C J, Evans M J, Schenken L L, Burholt D R
Cell Tissue Kinet. 1981 May;14(3):241-50. doi: 10.1111/j.1365-2184.1981.tb00529.x.
Changes in the growth kinetics of the intestinal epithelium were observed in mice bearing the Lewis lung carcinoma and the T1699 mammary adenocarcinoma and in rats bearing the H-4-II-E2 hepatoma. Proliferative activity in the jejunal tissue was markedly depressed with increasing tumour burden. Simultaneously, a significant reduction in total crypt cellularity occurred, followed by a reduction in villus height. While the total number of proliferative cells per crypt decreased, the relative proliferative compartment within the shrinking crypt increased. The rate of mucosal DNA synthesis remained constant during the initial cytokinetic changes, falling only after proliferative activity of the intestine was reduced to less than 50% of control levels. No general correlation could be drawn from the three tumour models studied between the level of gastrointestinal proliferation and tumour size, tumour growth rate or loss of weight by the tumour-bearing animals. However, intestinal proliferation was reduced by 50% when the tumour burden for each of the three tumours reached 6--8% of the host animal weight.
在携带Lewis肺癌和T1699乳腺腺癌的小鼠以及携带H-4-II-E2肝癌的大鼠中，观察到肠道上皮生长动力学的变化。随着肿瘤负荷增加，空肠组织中的增殖活性显著降低。同时，隐窝细胞总数显著减少，随后绒毛高度降低。虽然每个隐窝中增殖细胞的总数减少，但在缩小的隐窝内相对增殖区增加。在最初的细胞动力学变化期间，粘膜DNA合成速率保持恒定，仅在肠道增殖活性降低至对照水平的50%以下后才下降。在所研究的三种肿瘤模型中，胃肠道增殖水平与肿瘤大小、肿瘤生长速率或荷瘤动物体重减轻之间没有普遍的相关性。然而，当三种肿瘤中的每一种的肿瘤负荷达到宿主动物体重的6-8%时，肠道增殖减少了50%。
