Gorsky J E, Dietz A A, Spencer H, Osis D
Clin Chem. 1979 Oct;25(10):1739-43.
The metabolism of aluminum was followed in patients who were receiving strictly controlled diets, either unaltered or supplemented with aluminum-containing antacids. Aluminum was determined by atomic absorption spectrophotometry with a graphite furnace. All food, water, and medications were analyzed, as were aliquots of urine and stool collected throughout six-day periods. Patients were usually studied for five consecutive six-day periods on the same diet and aluminum intake. This study included six patients who were studied for seven to 21 such six-day periods. During control periods, when the patients were receiving less than 5 mg of aluminum per day, the balance was usually slightly negative, but when the diet was supplemented with antacids to contain 1--3 g of aluminum per day, an average positive balance of 23 to 313 mg of aluminum per day was observed for the total time on the same intake. Consecutive six-day periods while a subject was receiving antacids might show either positive or negative balances, but the average retention for 18--84 days on antacids was always positive. Thus the potential effects of the storage of aluminum in the tissues must be considered in the chronic administration of antacids.
对接受严格控制饮食（未改变或补充含铝抗酸剂）的患者的铝代谢情况进行了跟踪研究。采用石墨炉原子吸收分光光度法测定铝含量。对所有食物、水和药物进行了分析，同时对连续六天收集的尿液和粪便样本也进行了分析。患者通常在相同饮食和铝摄入量的情况下连续进行五个为期六天的研究阶段。该研究纳入了六名患者，他们接受了七至二十一个这样的为期六天的研究阶段。在对照期，当患者每天摄入的铝少于5毫克时，平衡通常略呈负值，但当饮食中补充抗酸剂使铝含量达到每天1 - 3克时，在相同摄入量的整个时间段内，观察到铝的平均正平衡为每天23至313毫克。受试者服用抗酸剂期间连续的六天阶段可能显示正平衡或负平衡，但在抗酸剂治疗18 - 84天的平均潴留量始终为正。因此，在长期使用抗酸剂时，必须考虑铝在组织中蓄积的潜在影响。
