Söderström N, Telenius-Berg M, Akerman M
Acta Med Scand. 1975 Jan-Feb;197(1-2):71-6. doi: 10.1111/j.0954-6820.1975.tb04880.x.
Fine needle aspiration biopsy has been evaluated as a diagnostic method for medullary carcinoma of the thyroid (MCT) in 18 patients with verified hereditary or sporadic MCT. The typical MCT cell was asymmetrical, sometimes triangular and often with a characteristic red granulation in May-Grünwald-Giemsa staining. Eccentrically positioned, multiple nuclei were common. Amyloid was seen both intra- and extracellularly, staining blue-grey or violet with May-Grünwald-Giemsa and with green birefringence in polarized light after staining with alkaline Congo. The method was simple and quick to perform, causing negligible discomfort to the patient. No complications were seen. An adequate bioptic yield was obtained in 15 patients. In 13 of them (87 percent), including one patient with a normal thyroid at clinical examination, a correct diagnosis was reached.
对18例经证实患有遗传性或散发性甲状腺髓样癌（MCT）的患者，评估了细针穿刺活检作为甲状腺髓样癌诊断方法的效果。典型的MCT细胞不对称，有时呈三角形，在May-Grünwald-Giemsa染色中常具有特征性的红色颗粒。多个细胞核偏心定位很常见。淀粉样蛋白在细胞内和细胞外均可见，在May-Grünwald-Giemsa染色中呈蓝灰色或紫色，在用碱性刚果红染色后在偏振光下呈绿色双折射。该方法操作简单、快捷，给患者带来的不适可忽略不计。未观察到并发症。15例患者获得了足够的活检标本。其中13例（87%），包括1例临床检查甲状腺正常的患者，得出了正确的诊断。
