Richens E R, Quilley J, Hartog M
Clin Exp Immunol. 1979 May;36(2):198-204.
Ninety-six juvenile onset type diabetics showed an increase in the frequency of HLA B8 and B15 and a decrease in frequency of HLA B7 antigens. Sixty-four maturity onset diabetics showed no disturbance in the frequency of these antigens. Fifty-four of the juvenile onset type diabetics, with an average duration of disease of 3.2 years were tested for the presence of islet cell antibodies (ICAs). Thirty-two per cent were positive, the incidence decreasing from 70% in those patients tested within 1 year of diagnosis to zero in those patients tested within 1 year of diagnosis to zero in those patients tested more than 5 years after diagnosis. No correlation was found between the incidence of ICAs and either cell-mediated immune reactions or HLA type. B15 positive patients were associated with cell-mediated immune reactions to pancreatic antigens and with the presence of other tissue autoantibodies. HLA phenotypes were not associated with environmental data. Diabetic siblings had identical HLA A-B haplotypes more often than could be expected to occur by chance.
96例青少年发病型糖尿病患者显示HLA B8和B15频率增加，HLA B7抗原频率降低。64例成年发病型糖尿病患者这些抗原的频率未出现紊乱。对54例平均病程为3.2年的青少年发病型糖尿病患者检测胰岛细胞抗体（ICA）的存在情况。32%呈阳性，发病率从诊断后1年内检测的患者中的70%降至诊断后5年以上检测的患者中的零。未发现ICA发病率与细胞介导的免疫反应或HLA类型之间存在相关性。B15阳性患者与针对胰腺抗原的细胞介导的免疫反应以及其他组织自身抗体的存在有关。HLA表型与环境数据无关。糖尿病同胞具有相同HLA A - B单倍型的情况比偶然预期发生的更为常见。
