Patterson R, Oh S H, Roberts M, Hsu C C
Am J Med. 1975 Apr;58(4):553-8. doi: 10.1016/0002-9343(75)90130-8.
A patient (E.M.) with marked eosinophilia and hyperimmunoglobulin E (IgE) has been followed for 4 years. Peripheral blood eosinophilia reached levels in excess of 18,000 cells/mm3 and serum IgE concentration increased to more than 210,000 units/ml (about 0.48 mg IgE/ml). The IgE has both lambda and kappa light chains and is therefore considered polyclonal. The patient has an increase in peripheral blood lymphocytes which stain for surface IgE. Transfer of the patient's plasma (plasmsEM) to a rhesus monkey did not induce peripheral boood eosinophilia. The half life of IgEEM in a rhesus monkey was 2.2 days, which is similar to the half life of myeloma IgE in human subjects. The condition was not associated with defined morbidity except for mild persistent pruritus. Various studies revealed no evidence for atopic parasitic, immune deficiency or neoplastic disease.
一名患有明显嗜酸性粒细胞增多症和高免疫球蛋白E（IgE）的患者（E.M.）已被随访4年。外周血嗜酸性粒细胞增多症达到超过18,000个细胞/mm³的水平，血清IgE浓度增加到超过210,000单位/ml（约0.48mg IgE/ml）。该IgE同时具有λ和κ轻链，因此被认为是多克隆的。该患者外周血中表面IgE染色的淋巴细胞增多。将患者的血浆（plasmsEM）转移到恒河猴体内并未诱导外周血嗜酸性粒细胞增多症。恒河猴体内IgEEM的半衰期为2.2天，这与人类受试者中骨髓瘤IgE的半衰期相似。除了轻度持续性瘙痒外，该病症未伴有明确的发病率。各种研究均未发现特应性、寄生虫、免疫缺陷或肿瘤性疾病的证据。
