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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Cook I F, Lloyd-Jones J G, Rees H H, Goodwin T W

Biochem J. 1973 Sep;136(1):135-45. doi: 10.1042/bj1360135.

[7alpha-(3)H(1)]- and [7beta-(3)H(1)]-Cholesterol were synthesized by a modified method. 2. The stereochemistry of Delta(7)-bond formation during ecdysone and ecdysterone biosynthesis in the insect, Calliphora erythrocephala and the plants, Taxus baccata and Polypodium vulgare was investigated by using [4-(14)C,7alpha-(3)H(1)]cholesterol and [4-(14)C,7beta-(3)H(1)]cholesterol. 3. In each case, the 7beta hydrogen was stereospecifically eliminated. 4. The possible significance of the results is discussed in relation to double-bond formation in other systems and the stage at which the Delta(7) bond is introduced during ecdysone biosynthesis.

通过改良方法合成了[7α-(3)H(1)]-胆固醇和[7β-(3)H(1)]-胆固醇。2. 利用[4-(14)C,7α-(3)H(1)]胆固醇和[4-(14)C,7β-(3)H(1)]胆固醇，研究了红头丽蝇、欧洲红豆杉和普通水龙骨中蜕皮激素和蜕皮甾酮生物合成过程中Δ(7)键形成的立体化学。3. 在每种情况下，7β氢都被立体定向消除。4. 结合其他系统中的双键形成以及蜕皮激素生物合成过程中引入Δ(7)键的阶段，讨论了这些结果可能具有的意义。

Cook I F, Lloyd-Jones J G, Rees H H, Goodwin T W

Biochem J. 1973 Sep;136(1):135-45. doi: 10.1042/bj1360135.

[7alpha-(3)H(1)]- and [7beta-(3)H(1)]-Cholesterol were synthesized by a modified method. 2. The stereochemistry of Delta(7)-bond formation during ecdysone and ecdysterone biosynthesis in the insect, Calliphora erythrocephala and the plants, Taxus baccata and Polypodium vulgare was investigated by using [4-(14)C,7alpha-(3)H(1)]cholesterol and [4-(14)C,7beta-(3)H(1)]cholesterol. 3. In each case, the 7beta hydrogen was stereospecifically eliminated. 4. The possible significance of the results is discussed in relation to double-bond formation in other systems and the stage at which the Delta(7) bond is introduced during ecdysone biosynthesis.

通过改良方法合成了[7α-(3)H(1)]-胆固醇和[7β-(3)H(1)]-胆固醇。2. 利用[4-(14)C,7α-(3)H(1)]胆固醇和[4-(14)C,7β-(3)H(1)]胆固醇，研究了红头丽蝇、欧洲红豆杉和普通水龙骨中蜕皮激素和蜕皮甾酮生物合成过程中Δ(7)键形成的立体化学。3. 在每种情况下，7β氢都被立体定向消除。4. 结合其他系统中的双键形成以及蜕皮激素生物合成过程中引入Δ(7)键的阶段，讨论了这些结果可能具有的意义。