普通水龙骨中蜕皮甾体A/B顺式环连接的形成机制。
Mechanism of formation of the A/B cis ring junction of ecdysteroids in Polypodium vulgare.
作者信息
Davies T G, Lockley W J, Boid R, Rees H H, Goodwin T W
出版信息
Biochem J. 1980 Sep 15;190(3):537-44. doi: 10.1042/bj1900537.
Abstract
- The fates of the alpha-, 4 alpha- and 4 beta-hydrogen atoms of cholesterol during formation of the A/B cis ring junction of ecdysteroids was investigated by administration of [4-14C, 3 alpha-3H], [4-14C, 4 alpha-3H]- and [4-14C, 4 beta-3H]cholesterol species to the fern, Polypodium vulgare, and isolation of the 20-hydroxyecdysone formed in each case. 2. The 3H was retained in the ecdysteroid formed from each substrate. 3. Location of the 3H in the 20-hydroxyecdysone indicated that migration of 3H from the 3 alpha- and 4 beta-positions to C-4 and C-5, respectively, had occurred, whereas the 4 alpha-3H atom was retained at C-4. 4. A possible mechanism for the formation of the A/B cis ring junction of ecdysteroids in P. vulgare is presented.
摘要
- 通过向普通水龙骨蕨施用[4-¹⁴C, 3α-³H]、[4-¹⁴C, 4α-³H]和[4-¹⁴C, 4β-³H]胆固醇类物质，并分离每种情况下形成的20-羟基蜕皮激素，研究了蜕皮激素A/B顺式环连接形成过程中胆固醇α-、4α-和4β-氢原子的命运。2. ³H保留在由每种底物形成的蜕皮激素中。3. ³H在20-羟基蜕皮激素中的位置表明，³H分别从3α-和4β-位迁移至C-4和C-5，而4α-³H原子保留在C-4位。4. 提出了普通水龙骨蕨中蜕皮激素A/B顺式环连接形成的一种可能机制。
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