3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁诱导的卟啉症大鼠肝脏中的核糖核酸合成
Ribonucleic acid synthesis in porphyric rat liver induced by 3,5-dicarbethoxy-1,4-dihydrocollidine.
作者信息
Nawata H, Kato K
出版信息
Biochem J. 1973 Sep;136(1):209-15. doi: 10.1042/bj1360209.
Abstract
- Administration of 3,5-dicarbethoxy-1,4-dihydrocollidine to rats caused a marked increase in the activity of delta-aminolaevulinic acid synthetase as well as a slight net increase in RNA in the livers. 2. 3,5-Dicarbethoxy-1,4-dihydrocollidine primarily stimulated the synthesis of RNA in the nucleus of the liver cell. 3. The decrease in RNA synthesis after administration of this drug resulted in a rapid decrease in the activity of this induced enzyme. This was also confirmed by treatment with actinomycin D. 4. From kinetic experiments on synthesis of RNA and delta-aminolaevulinic acid synthetase in vivo the induction mechanism of this enzyme was discussed.
摘要
- 给大鼠注射3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁，导致肝脏中δ - 氨基乙酰丙酸合成酶的活性显著增加，同时肝脏中的RNA也有轻微的净增加。2. 3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁主要刺激肝细胞细胞核中RNA的合成。3. 注射该药物后RNA合成的减少导致这种诱导酶的活性迅速下降。这也通过放线菌素D处理得到证实。4. 通过对体内RNA和δ - 氨基乙酰丙酸合成酶合成的动力学实验，讨论了该酶的诱导机制。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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